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PUBLICATIONS

  • Tal Levy*, Kai Voeltzke*, Laura Hruby*, Khawla Alasad*, Zuelal Bas, Marteinn Snaebjörnsson, Ran Marciano, Katerina Scharov, Mélanie Planque, Kim Vriens, Stefan Christen, Cornelius M. Funk, Christina Hassiepen, Alisa Kahler, Beate Heider, Daniel Picard, Jonathan K. M. Lim, Anja Stefanski, Katja Bendrin, Andres Vargas-Toscano, Ulf D. Kahlert, Kai Stühler, Marc Remke, Moshe Elkabets, Thomas G. P. Grünewald, Andreas S. Reichert, Sarah-Maria Fendt, Almut Schulze, Guido Reifenberger, Barak Rotblat# & Gabriel Leprivier#. mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism. 15, 4083 (2024). Link *equal contribution; #co-corresponding

  • Galai G, He X, Rotblat B, Pilosof S.  Ecological network analysis reveals cancer-dependent chaperone-client interaction structure and robustness. Nat Commun. 2023 Oct 7;14(1):6277. doi: 10.1038/s41467-023-41906-2

  • Bartl J, Zanini M, Bernardi F, Forget A, Blümel L, Talbot J, Picard D, Qin N, Cancila G, Gao Q, Nath S, Koumba IM, Wolter M, Kuonen F, Langini M, Beez T, Munoz C, Pauck D, Marquardt V, Yu H, Souphron J, Korsch M, Mölders C, Berger D, Göbbels S, Meyer FD, Scheffler B, Rotblat B, Diederichs S, Ramaswamy V, Suzuki H, Oro A, Stühler K, Stefanski A, Fischer U, Leprivier G, Willbold D, Steger G, Buell A, Kool M, Lichter P, Pfister SM, Northcott PA, Taylor MD, Borkhardt A, Reifenberger G, Ayrault O, Remke M. The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors. Nat Commun. 2022 Jul 13;13(1):4061

  • Voeltzke K, Scharov K, Funk CM, Kahler A, Picard D, Hauffe L, Orth MF, Remke M, Esposito I, Kirchner T, Schramm A, Rotblat B, Grünewald TGP, Reifenberger G, Leprivier G. EIF4EBP1 is transcriptionally upregulated by MYCN and associates with poor prognosis in neuroblastoma. Cell Death Discov 2022 Apr 4;8(1):157

  • Prasad M, Zorea J, Jagadeeshan S, Shnerb AB, Mathukkada S, Bouaoud J, Michon L, Novoplansky O, Badarni M, Cohen L, Yegodayev KM, Tzadok S, Rotblat B, Brezina L, Mock A, Karabajakian A, Fayette J, Cohen I, Cooks T, Allon I, Dimitstein O, Joshua B, Kong D, Voronov E, Scaltriti M, Carmi Y, Conde-Lopez C, Hess J, Kurth I, Morris LGT, Saintigny P, Elkabets M. MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer. J Immunother Cancer. 2022 Mar;10(3):e003917.

  • Hauffe L, Picard D, Musa J, Remke M, Grünewald TGP, Rotblat B, Reifenberger G, Leprivier G. Eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) expression in glioblastoma is driven by ETS1- and MYBL2-dependent transcriptional activation. Cell Death and Discovery, 2022

  • Mazor G, Smirnov D, Ben David H, Khrameeva E, Toiber D, Rotblat B. TP73-AS1 is induced by YY1 during TMZ treatment and highly expressed in the aging brain. Aging (Albany NY). 2021 Jun 11;13(11):14843-14861. Link

  • Badarni M, Prasad M, Golden A, Bhattacharya B, Levin L, Yegodayev KM, Dimitstein O, Joshua BZ, Cohen L, Khrameeva E, Kong D, Porgador A, Braiman A, Grandis JR, Rotblat B*, Elkabets M*. IGF2 Mediates Resistance to Isoform-Selective-Inhibitors of the PI3K in HPV Positive Head and Neck Cancer. Cancers. 2021 May 7;13(9):2250. Link

  • Vershinin Z, Feldman M, Werner T, Weil LE, Kublanovsky M, Abaev-Schneiderman E, Sklarz M, Lam EYN, Alasad K, Picaud S, Rotblat B, McAdam RA, Chalifa-Caspi V, Bantscheff M, Chapman T, Lewis HD, Filippakopoulos P, Dawson MA, Grandi P, Prinjha RK, Levy D. BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation. Sci Adv. 2021 May 26;7(22):eabf5374. Link

  • Alasad K, Voeltzke K, Levin L, Reifenberger G, Leprivier G, Rotblat B. 4EBP1/2 are active under standard cell culture conditions to regulate the translation of specific mRNAs. ell Death Dis. 2020 Nov 11;11(11):968. Link

  • Leprivier G, Rotblat B. How does mTOR sense glucose starvation? AMPK is the usual suspect. Cell Death Discov. 2020;6(1):0–4. Link

  • Galai, Geut, Hila Ben-David, Liron Levin, Martin F. Orth, Thomas G.P. Grunewald, Shai Pilosof, Shimon Bershtein, and Barak Rotblat. Pan-Cancer Analysis of Mitochondria Chaperone-Client Co-Expression Reveals Chaperone Functional Partitioning. Cancers. 2020;12(4):825. Available from: https://www.mdpi.com/2072-6694/12/4/825

  • Musa, J; Cidre-Aranaz, F; Aynaud, MM; Orth, MF; Knott, MML; Mirabeau, O; Mazor, G; Varon, M; Holting, TLB; Grossetete, S; Gartlgruber, M; Surdez, D; Gerke, JS; Ohmura, S; Marchetto, A; Dallmayer, M; Baldauf, MC; Stein, S; Sannino, G; Li, J; Romero-Perez, L; Westermann, F; Hartmann, W; Dirksen, U; Gymrek, M; Anderson, ND; Shlien, A; Rotblat, B; Kirchner, T; Delattre, O; Grunewald, TGP. Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes. Nat Commun. 2019;10(1):4128. Available from: http://dx.doi.org/10.1038/s41467-019-12071-2

  • Badarni, M; Prasad, M; Balaban, N; Zorea, J; Yegodayev, KM; Ben-Zion, J; Dinuri, AB; Grenman, R; Rotblat, B; Cohen, L; Elkabets, M. Repression of AXL expression by AP-1/JNK blockage overcomes resistance to PI3Ka therapy. JCI insight. 2019 Mar;5(8):e125341.

  • Mazor, G; Levin, L; Picard, D; Ahmadov, U; Caren, H; Borkhardt, A; Reifenberger, G; Leprivier, G; Remke, M; Rotblat, B; The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem cells. Cell Death Dis [Internet]. 2019;10(3):246. Available from: http://www.nature.com/articles/s41419-019-1477-5

  • Varon, M; Levy, T; Mazor, G; Ben David, H; Marciano, R; Krelin, Y; Prasad, M; Elkabets, M; Pauck, D; Ahmadov, U; Picard, D; Qin, N; Borkhardt, A; Reifenberger, G; Leprivier, G; Remke, M; Rotblat, B. The long non‐coding RNA TP73‐AS1 promotes tumorigenicity of medulloblastoma cells. Int J Cancer [Internet]. 2019;145(12):3402–13. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32400

  • Marciano, R; Prasad, M; Ievy, T; Tzadok, S; Leprivier, G; Elkabets, M; Rotblat, B. High-Throughput Screening Identified Compounds Sensitizing Tumor Cells to Glucose Starvation in Culture and VEGF Inhibitors In Vivo. Cancers (Basel) [Internet]. 2019 Jan 30 [cited 2019 Apr 24];11(2):156. Available from: http://www.ncbi.nlm.nih.gov/pubmed/30704052

  • Halperin, D; Kadir, R; Perez, Y; Drabkin, M; Yogev, Y; Wormser, O; Berman, EM; Eremenko, E; Rotblat, B; Shorer, Z; Gradstein, L; Shelef, I; Birk, R; Abdu, U; Flusser, H; Birk, OS. SEC31A mutation affects ER homeostasis, causing neurological syndrome. J Med Genet [Internet]. 2018;jmedgenet-2018-105503. Available from: http://jmg.bmj.com/lookup/doi/10.1136/jmedgenet-2018-105503

  • Rotblat B, Agostini M, Niklison-chirou MV, Amelio I, Willis AE, Melino G. Sustained protein synthesis and reduced eEF2K levels in TAp73 - \ - mice brain : a possible compensatory mechanism. Cell Cycle. 2018;17(23):2637–43.

  • Zorea, J; Prasad, M; Cohen, L; Li, N; Schefzik, R; Ghosh, S; Rotblat, B; Brors, B; Elkabets, M. IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer. Cell Death Dis [Internet]. 2018 Oct 20 [cited 2018 Oct 7];9(10):944. Available from: http://www.ncbi.nlm.nih.gov/pubmed/30237504

  • De S, Levin L, Rotblat B. lncRNA in worms – Time to meet the neighbors. Curr Opin Syst Biol [Internet]. 2018;13:1–6. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2452310018300623; PDF

  • Marini A, Rotblat B, Sbarrato T, Niklison-chirou MV, Knight JRP. TAp73 contributes to the oxidative stress response by regulating protein synthesis. PNAS. 2018;115(24):6219–24.

  • Marciano R, Leprivier G, Rotblat B. Puromycin labeling does not allow protein synthesis to be measured in energy-starved cells correspondence. Cell Death Dis. 2018;9(2).

  • Bar M, Rotblat B, Rechavi O. Point of View: Nomad scientists and the ones left behind. Elife. 2017;6.

  • Toiber D, Leprivier G, Rotblat B. Long noncoding RNA: noncoding and not coded. Cell Death Discov [Internet]. 2017;3:16104. Available from: http://www.nature.com/articles/cddiscovery2016104

  • Musa, J; Orth, MF; Dallmayer, M; Baldauf, M; Pardo, C; Rotblat, B; Kirchner, T; Leprivier, G; Grunewald, TGP. Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis. Oncogene [Internet]. 2016 Feb 1 [cited 2016 Apr 7];1(October 2015):1–14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26829052

  • Cetinbas, N; Daugaard, M; Mullen, AR; Hajee, S; Rotblat, B; Lopez, A; Li, A; DeBerardinis, RJ; Sorensen, PH. Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction. Oncogene. 2015;34(30):4005–10.

  • Leprivier G, Rotblat B, Khan D, Jan E, Sorensen PH. Stress-mediated translational control in cancer cells. Biochim Biophys Acta - Gene Regul Mech. 2015;1849(7):845–60; PDF 

  • Rotblat B, Grunewald TGP. Translating cancer-omics into function. Biol cell. 2015 May 29;(00):1–2.

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