Molecular biology of cancer
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PEOPLE

Sonia Soreanu
Lab manager
sorenau@bgu.ac.il
Sonia Soreanu, lab manager
soreanu@bgu.ac.il 
Sveta Grodzinsky
Administrative assistant
svetag@bgu.ac.il
Tal Lavy, PhD candidate
levyag@post.bgu.ac.il
Khawla Alasad, PhD candidate
Khawla@post.bgu.ac.il
Mai Badarni, PhD candidate
maibdarny@gmail.com
Geut Galai, MSc candidate
geutg@post.bgu.ac.il
Shir Orenstein, BSc candidate
shirore@post.bgu.ac.il
Hanin Aburfiah, MSc candidate
h-a-f-1996@hotmail.com
Orli Korchev, BSc candidate
orlikor@post.bgu.ac.il
 

publications

Our conference format is published in Nature blogs

Ran MarcianoHila Ben DavidBarak AkabayovBarak Rotblat;The Amuvatinib Derivative, N-(2H-1,3-Benzodioxol-5-yl)-4-{thieno[3,2-d]pyrimidin-4-yl}piperazine-1-carboxamide, Inhibits Mitochondria and Kills Tumor Cells Under Glucose Starvation; International Journal of Molecular Sciences; 2020 Feb 4; 21 (3):E1041

Julian Musa, Florencia Cidre-Aranaz, Marie-Ming Aynaud, Martin F. Orth, Maximilian M. L. Knott, Olivier Mirabeau, Gal Mazor, Mor Varon, Tilman L. B. Hölting, Sandrine Grossetête, Moritz Gartlgruber, Didier Surdez, Julia S. Gerke, Shunya Ohmura, Aruna Marchetto, Marlene Dallmayer, Michaela C. Baldauf, Stefanie Stein, Giuseppina Sannino, Jing Li, Laura Romero-Pérez, Frank Westermann, Wolfgang Hartmann, Uta Dirksen, Melissa Gymrek, Nathaniel D. Anderson, Adam Shlien, Barak Rotblat, Thomas Kirchner, Olivier Delattre, and Thomas G. P. Grünewald; Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes; Nature Communications; 2019 (10):4128;

Varon M*, Levy T*, Mazor G, Ben David H, Marciano R, Kerlin Y, Prasad M, Elkabets M, Pauck D, Ahmadov U, Picard D, Qin N, Borkhardt A, Reifenberger G, Leprivier G, Remke M, Rotblat B†; The long noncoding RNA TP73-AS1 promotes medulloblastoma; International Journal of Cancer, 145 (12), 3402-3413

*equal contribution

 

Mai Badarni, Manu Prasad, Noa Balaban, Jonatan Zorea, Ksenia Yagodayev, Joshua Ben-Zion, Anat Bahat Dinur, Reidar Grénman, Barak Rotblat, Limor Cohen, Moshe Elkabets

Repression of AXL expression by AP-1/JNK blockage overcomes resistance to PI3Ka therapy

JCI Insight, 5(8)

 

Gal MazorS, Liron LevinT, Daniel PicardPD, Ulvi AhmadovS, Arndt BorkhardtC, Guido ReifenbergerC, Gabriel LeprivierC, Marc RemkeC, Barak Rotblat

The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem cells

Cell Death and Disease 2019 Mar 13;10(3):246 

 

Marciano R, Prasad M, Ievy T, Tzadok S, Leprivier G, Elkabets M, Rotblat B

High-Throughput Screening Identified Compounds Sensitizing Tumor Cells to Glucose Starvation in Culture and VEGF Inhibitors In Vivo.

Cancers (Basel). 2019 Jan 30;11(2). pii: E156. doi: 10.3390/cancers11020156.

 

Rotblat B†, Agostini A, Niklison-Chirou MV, Amelio I,

Willis AE†, Melino G.†

Sustained protein synthesis and reduced eEF2K levels in TAp73-\- mice brain: a possible compensatory mechanism.

Cell Cycle 2018 Dec 17(23):2637-2643

† Corresponding authors

 

Halperin D, Kadir R, Perez Y, Drabkin M, Yogev Y, Wormser O, Berman EM, Eremenko E, Rotblat B, Shorer Z, Gradstein L, Shelef I, Birk R, Abdu U, Flusser H, Birk OS

SEC31A mutation affects ER homeostasis, causing neurological syndrome.

J Med Genet. 2018 Nov 21

 

Zorea J, Prasad M, Cohen L, Li N, Schefzik R, Ghosh S, Rotblat B, Brors B, Elkabets M.

IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer.

Cell Death Dis. 2018 Sep 20;9(10):944. doi: 10.1038/s41419-018-1025-8.

 

Tognon CE, Rafn B, Cetinbas NM, Kamura T, Trigo G, Rotblat B, Okumura F, Matsumoto M, Chow C, Davare M, Pollak M, Mayor T, Sorensen PH.

Insulin-like growth factor 1 receptor stabilizes the ETV6-NTRK3 chimeric oncoprotein by blocking its KPC1/Rnf123-mediated proteasomal degradation.

J Biol Chem. 2018 Aug 10;293(32):12502-12515. doi: 10.1074/jbc.RA117.000321. Epub 2018 Jun 14.

 

Marini A*, Rotblat B* Sbarrato T, Niklison-Chirou MV, Knight JRP, Dudek K, Jones C, Bushell M, Knight RA, Amelio I, Willis AE, Melino G.

TAp73 contributes to the oxidative stress response by regulating protein synthesis.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6219-6224. doi: 10.1073/pnas.1718531115. Epub 2018 May 29.

* Equal contribution

 

Marciano R, Leprivier G, Rotblat B
Puromycin labeling does not allow protein synthesis to be measured in energy-starved cells.
Cell Death Dis. 2018 Jan 18;9(2):39. doi: 10.1038/s41419-017-0056-x.

 

Toiber, Leprivier, Rotblat B*

Long noncoding RNA: noncoding and not coded.

Cell Death Discov. 2017 Jan 9;3:16104

*corresponding author

 

Musa J, Orth FM, Dallmayer M, Baldauf M, Pardo M, Rotblat B, Kirchner T, Leprivier G, Grünewald TG

Eukaryotic initiation factor 4E binding protein 1 (4E-BP1): A master regulator of mRNA translation involved in tumorigenesis

Oncogene, 2016 (1),1-14

 

*Rotblat B, *Grunewald T.

Translating cancer-omics into function

Biology of the Cell 2015 00, 1-2

*corresponding author

Editorial

CONTACT

Barak Rotblat

     orcid.org/0000-0003-2985-7115
rotblat(at)bgu(dot)ac(dot)il
or barak(dot)rotblat(at)gmail(dot)com
Office: +972 (0)8-6428806
Lab: +972 (0)8-6472119
Fax: +972 (0)8-6428920

Twitter: @BarakRotblat
Linkedin: www.linkedin.com/in/barak-rotblat/
Facebook: www.facebook.com/RotblatLab/

Barak Rotblat, PhD
Department of Life Sciences
Building 40, Room 011
Ben-Gurion University of the Negev
8410501
Israel

 

Our Research

a scheme of lncRNA function
a scheme of polysmes
a schemeof mitochondria

long noncoding RNA

how these transcripts contribute to tumor cells

mRNA translation

cancer metabolism

not all mRNA are translated equally - what are tumors translating? 

understanding how tumor cells cope with metabolic stress

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